Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection

We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters. Intranasal administration of BV-AdCoV-1 elicited strong humoral a...

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Detalles Bibliográficos
Autores principales: Wang, Shen, Xu, Long, Mu, Ting, Qin, Mian, Zhao, Ping, Xie, Liang, Du, Linsen, Wu, Yue, Legrand, Nicolas, Mouchain, Karine, Fichet, Guillaume, Liu, Yi, Yin, Wenhao, Zhao, Jin, Ji, Min, Gong, Bo, Klein, Michel, Wu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671113/
https://www.ncbi.nlm.nih.gov/pubmed/36405962
http://dx.doi.org/10.3389/fcimb.2022.979641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671113/
https://www.ncbi.nlm.nih.gov/pubmed/36405962
http://dx.doi.org/10.3389/fcimb.2022.979641

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