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Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection
We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters. Intranasal administration of BV-AdCoV-1 elicited strong humoral a...
Autores principales: | Wang, Shen, Xu, Long, Mu, Ting, Qin, Mian, Zhao, Ping, Xie, Liang, Du, Linsen, Wu, Yue, Legrand, Nicolas, Mouchain, Karine, Fichet, Guillaume, Liu, Yi, Yin, Wenhao, Zhao, Jin, Ji, Min, Gong, Bo, Klein, Michel, Wu, Ke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671113/ https://www.ncbi.nlm.nih.gov/pubmed/36405962 http://dx.doi.org/10.3389/fcimb.2022.979641 |
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