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Fast-forwarding evolution—Accelerated adaptation in a proofreading-deficient hypermutator herpesvirus
Evolution relies on the availability of genetic diversity for fitness-based selection. However, most deoxyribonucleic acid (DNA) viruses employ DNA polymerases (Pol) capable of exonucleolytic proofreading to limit mutation rates during DNA replication. The relative genetic stability produced by high...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671156/ https://www.ncbi.nlm.nih.gov/pubmed/36405341 http://dx.doi.org/10.1093/ve/veac099 |