Fast-forwarding evolution—Accelerated adaptation in a proofreading-deficient hypermutator herpesvirus

Evolution relies on the availability of genetic diversity for fitness-based selection. However, most deoxyribonucleic acid (DNA) viruses employ DNA polymerases (Pol) capable of exonucleolytic proofreading to limit mutation rates during DNA replication. The relative genetic stability produced by high...

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Detalles Bibliográficos
Autores principales: Xing, Na, Höfler, Thomas, Hearn, Cari J, Nascimento, Mariana, Camps Paradell, Georgina, McMahon, Dino P, Kunec, Dusan, Osterrieder, Nikolaus, Cheng, Hans H, Trimpert, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671156/
https://www.ncbi.nlm.nih.gov/pubmed/36405341
http://dx.doi.org/10.1093/ve/veac099

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