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SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly
CTL-mediated killing of virally infected or malignant cells is orchestrated at the immune synapse (IS). We hypothesized that SARS-CoV-2 may target lytic IS assembly to escape elimination. We show that human CD8(+) T cells upregulate the expression of ACE2, the Spike receptor, during differentiation...
Main Authors: | , , , , , , , , , , , |
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Format: | Online Article Text |
Language: | English |
Published: |
Rockefeller University Press
2022
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Subjects: | |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671159/ https://www.ncbi.nlm.nih.gov/pubmed/36378226 http://dx.doi.org/10.1084/jem.20220906 |