SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

CTL-mediated killing of virally infected or malignant cells is orchestrated at the immune synapse (IS). We hypothesized that SARS-CoV-2 may target lytic IS assembly to escape elimination. We show that human CD8(+) T cells upregulate the expression of ACE2, the Spike receptor, during differentiation...

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Detalles Bibliográficos
Autores principales: Onnis, Anna, Andreano, Emanuele, Cassioli, Chiara, Finetti, Francesca, Della Bella, Chiara, Staufer, Oskar, Pantano, Elisa, Abbiento, Valentina, Marotta, Giuseppe, D’Elios, Mario Milco, Rappuoli, Rino, Baldari, Cosima T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671159/
https://www.ncbi.nlm.nih.gov/pubmed/36378226
http://dx.doi.org/10.1084/jem.20220906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671159/
https://www.ncbi.nlm.nih.gov/pubmed/36378226
http://dx.doi.org/10.1084/jem.20220906

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