Cargando…

SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

CTL-mediated killing of virally infected or malignant cells is orchestrated at the immune synapse (IS). We hypothesized that SARS-CoV-2 may target lytic IS assembly to escape elimination. We show that human CD8(+) T cells upregulate the expression of ACE2, the Spike receptor, during differentiation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onnis, Anna, Andreano, Emanuele, Cassioli, Chiara, Finetti, Francesca, Della Bella, Chiara, Staufer, Oskar, Pantano, Elisa, Abbiento, Valentina, Marotta, Giuseppe, D’Elios, Mario Milco, Rappuoli, Rino, Baldari, Cosima T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671159/ https://www.ncbi.nlm.nih.gov/pubmed/36378226 http://dx.doi.org/10.1084/jem.20220906

Ejemplares similares

Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange
por: Finetti, Francesca, et al.
Publicado: (2017)

Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC
por: Onnis, Anna, et al.
Publicado: (2020)

Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling
por: Paccani, Silvia Rossi, et al.
Publicado: (2005)

A Ciliary View of the Immunological Synapse
por: Cassioli, Chiara, et al.
Publicado: (2019)

Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis
por: Baldari, Cosima T., et al.
Publicado: (2023)

Lymphocyte Polarization During Immune Synapse Assembly: Centrosomal Actin Joins the Game
por: Cassioli, Chiara, et al.
Publicado: (2022)

Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set
por: Onnis, Anna, et al.
Publicado: (2016)

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time
por: Jenkins, Misty R., et al.
Publicado: (2015)

The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse
por: Paccani, Silvia Rossi, et al.
Publicado: (2011)

A T Cell Suppressive Circuitry Mediated by CD39 and Regulated by ShcC/Rai Is Induced in Astrocytes by Encephalitogenic T Cells
por: Ulivieri, Cristina, et al.
Publicado: (2019)

Orchestration of Immunological Synapse Assembly by Vesicular Trafficking
por: Onnis, Anna, et al.
Publicado: (2019)

Increasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells
por: Cassioli, Chiara, et al.
Publicado: (2021)

Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)
por: Cassioli, Chiara, et al.
Publicado: (2022)

The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells
por: Finetti, Francesca, et al.
Publicado: (2021)

IFT20: An Eclectic Regulator of Cellular Processes beyond Intraflagellar Transport
por: Finetti, Francesca, et al.
Publicado: (2022)

LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy
por: Capitani, Nagaja, et al.
Publicado: (2019)

Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells
por: Cattaneo, Francesca, et al.
Publicado: (2016)

Compartmentalized Cyclic AMP Production by the Bordetella pertussis and Bacillus anthracis Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes
por: Arumugham, Vijay B., et al.
Publicado: (2018)

The Expanding Arsenal of Cytotoxic T Cells
por: Cassioli, Chiara, et al.
Publicado: (2022)

Increased IL-17A Serum Levels and Gastric Th17 Cells in Helicobacter pylori-Infected Patients with Gastric Premalignant Lesions
por: Della Bella, Chiara, et al.
Publicado: (2023)

Beta 2 glycoprotein I and neutrophil extracellular traps: Potential bridge between innate and adaptive immunity in anti-phospholipid syndrome
por: Grossi, Claudia, et al.
Publicado: (2023)

Intrinsic factor recognition promotes T helper 17/T helper 1 autoimmune gastric inflammation in patients with pernicious anemia
por: Troilo, Arianna, et al.
Publicado: (2019)

A new dawn for monoclonal antibodies against antimicrobial resistant bacteria
por: Troisi, Marco, et al.
Publicado: (2022)

High-throughput bactericidal assays for monoclonal antibody screening against antimicrobial resistant Neisseria gonorrhoeae
por: Stazzoni, Samuele, et al.
Publicado: (2023)

The Helicobacter pylori Vacuolating Toxin Inhibits T Cell Activation by Two Independent Mechanisms
por: Boncristiano, Marianna, et al.
Publicado: (2003)

Multiple Sclerosis: The Role of Cytokines in Pathogenesis and in Therapies
por: Amedei, Amedeo, et al.
Publicado: (2012)

Exploiting the RUSH System to Study Lytic Granule Biogenesis in Cytotoxic T Lymphocytes
por: Capitani, Nagaja, et al.
Publicado: (2023)

The antigen CD300e drives T cell inflammation in adipose tissue and elicits an antibody response predictive of the insulin sensitivity recovery in obese patients
por: Coletta, Sara, et al.
Publicado: (2022)

What Is Recent in Pancreatic Cancer Immunotherapy?
por: Niccolai, Elena, et al.
Publicado: (2013)

Editorial: Modulation of the immune system by bacteria: From evasion to therapy
por: de Bernard, Marina, et al.
Publicado: (2023)

Novel M. tuberculosis specific IL-2 ELISpot assay discriminates adult patients with active or latent tuberculosis
por: Della Bella, Chiara, et al.
Publicado: (2018)

Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
por: Della Bella, Chiara, et al.
Publicado: (2022)

HP-NAP of Helicobacter pylori: The Power of the Immunomodulation
por: Codolo, Gaia, et al.
Publicado: (2022)

The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells
por: D’Elios, Mario Milco, et al.
Publicado: (2017)

Immunodominant antibody germlines in COVID-19
por: Andreano, Emanuele, et al.
Publicado: (2021)

Digital ulcers secondary to Sneddon’s syndrome successfully treated with Bosentan: not only useful in Systemic Sclerosis
por: Barnini, Tommaso, et al.
Publicado: (2012)

Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome
por: Benagiano, Marisa, et al.
Publicado: (2019)

Gastric Th17 Cells Specific for H(+)/K(+)-ATPase and Serum IL-17 Signature in Gastric Autoimmunity
por: Della Bella, Chiara, et al.
Publicado: (2022)

The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells
por: Casartelli, Nicoletta, et al.
Publicado: (2010)

The Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens
por: Capitani, Nagaja, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lus22vgd3rd7hf0tuiaudhok52