CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X

Fragile X syndrome (FXS) is a leading cause of inherited intellectual disability and autism. Whereas dysregulated RNA translation in Fmr1 knockout (KO) mice, a model of FXS, is well studied, little is known about aberrant transcription. Using single-molecule mRNA detection, we show that mRNA encodin...

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Detalles Bibliográficos
Autores principales: Hwang, Jee-Yeon, Monday, Hannah R., Yan, Jingqi, Gompers, Andrea, Buxbaum, Adina R., Sawicka, Kirsty J., Singer, Robert H., Castillo, Pablo E., Zukin, R. Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671216/
https://www.ncbi.nlm.nih.gov/pubmed/35675768
http://dx.doi.org/10.1016/j.celrep.2022.110853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671216/
https://www.ncbi.nlm.nih.gov/pubmed/35675768
http://dx.doi.org/10.1016/j.celrep.2022.110853

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