Cargando…
CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X
Fragile X syndrome (FXS) is a leading cause of inherited intellectual disability and autism. Whereas dysregulated RNA translation in Fmr1 knockout (KO) mice, a model of FXS, is well studied, little is known about aberrant transcription. Using single-molecule mRNA detection, we show that mRNA encodin...
Autores principales: | Hwang, Jee-Yeon, Monday, Hannah R., Yan, Jingqi, Gompers, Andrea, Buxbaum, Adina R., Sawicka, Kirsty J., Singer, Robert H., Castillo, Pablo E., Zukin, R. Suzanne |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671216/ https://www.ncbi.nlm.nih.gov/pubmed/35675768 http://dx.doi.org/10.1016/j.celrep.2022.110853 |
Ejemplares similares
-
GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons
por: Garst-Orozco, Jonathan, et al.
Publicado: (2020) -
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
por: Allen, Nicola J., et al.
Publicado: (2012) -
GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar–pillar morphology
por: Rutherford, Mark A, et al.
Publicado: (2023) -
Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation
por: Widagdo, Jocelyn, et al.
Publicado: (2015) -
R/G editing in GluA2R(flop) modulates the functional difference between GluA1 flip and flop variants in GluA1/2R heteromeric channels
por: Wen, Wei, et al.
Publicado: (2017)