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Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
Prion strains in a given type of mammalian host are distinguished by differences in clinical presentation, neuropathological lesions, survival time, and characteristics of the infecting prion protein (PrP) assemblies. Near-atomic structures of prions from two host species with different PrP sequence...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671466/ https://www.ncbi.nlm.nih.gov/pubmed/36342968 http://dx.doi.org/10.1371/journal.ppat.1010947 |