KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. Here, we report that the lysine acetyltransferases 2A and 2B (KAT2A/2B, also called GCN5/PCAF),...

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Detalles Bibliográficos
Autores principales: Fournier, Marjorie, Rodrigue, Amélie, Milano, Larissa, Bleuyard, Jean-Yves, Couturier, Anthony M, Wall, Jacob, Ellins, Jessica, Hester, Svenja, Smerdon, Stephen J, Tora, László, Masson, Jean-Yves, Esashi, Fumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671498/
https://www.ncbi.nlm.nih.gov/pubmed/36269050
http://dx.doi.org/10.7554/eLife.57736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671498/
https://www.ncbi.nlm.nih.gov/pubmed/36269050
http://dx.doi.org/10.7554/eLife.57736

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