Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex

Tetrameric voltage-gated K(+) channels have four identical voltage sensor domains, and they regulate channel gating. KCNQ1 (Kv7.1) is a voltage-gated K(+) channel, and its auxiliary subunit KCNE proteins dramatically regulate its gating. For example, KCNE3 makes KCNQ1 a constitutively open channel a...

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Detalles Bibliográficos
Autores principales: Kasuya, Go, Nakajo, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671499/
https://www.ncbi.nlm.nih.gov/pubmed/36331187
http://dx.doi.org/10.7554/eLife.81683