Trabectedin and lurbinectedin: Mechanisms of action, clinical impact, and future perspectives in uterine and soft tissue sarcoma, ovarian carcinoma, and endometrial carcinoma

The ecteinascidins trabectedin and lurbinectedin are very interesting antineoplastic agents, with a favorable toxicity profile and peculiar mechanisms of action. These drugs form adducts in the minor groove of DNA, which produce single-strand breaks (SSBs) and double-strand breaks (DSBs) and trigger...

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Detalles Bibliográficos
Autores principales: Gadducci, Angiolo, Cosio, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671549/
https://www.ncbi.nlm.nih.gov/pubmed/36408147
http://dx.doi.org/10.3389/fonc.2022.914342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671549/
https://www.ncbi.nlm.nih.gov/pubmed/36408147
http://dx.doi.org/10.3389/fonc.2022.914342

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