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Dynamics and energetics of PCBP1 binding to severely oxidized RNA

Oxidatively generated lesions such as 8-oxo-7, 8-dihydroguanine (8-oxoG) on RNA strands constitute a hallmark marker of the oxidative stress in the cell. Poly-C binding protein 1 (PCBP1) is able to specifically recognize severely damaged RNA strands containing two 8-oxoG lesions separated by five nu...

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Detalles Bibliográficos
Autores principales: Gillet, Natacha, Dumont, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671708/
https://www.ncbi.nlm.nih.gov/pubmed/36406269
http://dx.doi.org/10.3389/fmolb.2022.994915