New C3H Kit(N824K/WT) cancer mouse model develops late-onset malignant mammary tumors with high penetrance

Gastro-intestinal stromal tumors and acute myeloid leukemia induced by activating stem cell factor receptor tyrosine kinase (KIT) mutations are highly malignant. Less clear is the role of KIT mutations in the context of breast cancer. Treatment success of KIT-induced cancers is still unsatisfactory...

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Detalles Bibliográficos
Autores principales: Klein-Rodewald, Tanja, Micklich, Kateryna, Sanz-Moreno, Adrián, Tost, Monica, Calzada-Wack, Julia, Adler, Thure, Klaften, Matthias, Sabrautzki, Sibylle, Aigner, Bernhard, Kraiger, Markus, Gailus-Durner, Valerie, Fuchs, Helmut, Gründer, Albert, Pahl, Heike, Wolf, Eckhard, Hrabe de Angelis, Martin, Rathkolb, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671887/
https://www.ncbi.nlm.nih.gov/pubmed/36396684
http://dx.doi.org/10.1038/s41598-022-23218-5

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