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Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
Antigen recognition by the T cell receptor (TCR) of CD4(+) T cells can be greatly enhanced by the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra-low affinity of CD4 binding to class-II peptide-major histocompatibility complexes (pMHC). Here we show, using two-...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671906/ https://www.ncbi.nlm.nih.gov/pubmed/36396644 http://dx.doi.org/10.1038/s41467-022-34587-w |