Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity

Antigen recognition by the T cell receptor (TCR) of CD4(+) T cells can be greatly enhanced by the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra-low affinity of CD4 binding to class-II peptide-major histocompatibility complexes (pMHC). Here we show, using two-...

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Detalles Bibliográficos
Autores principales: Rushdi, Muaz Nik, Pan, Victor, Li, Kaitao, Choi, Hyun-Kyu, Travaglino, Stefano, Hong, Jinsung, Griffitts, Fletcher, Agnihotri, Pragati, Mariuzza, Roy A., Ke, Yonggang, Zhu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671906/
https://www.ncbi.nlm.nih.gov/pubmed/36396644
http://dx.doi.org/10.1038/s41467-022-34587-w

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