Activation and signaling mechanism revealed by GPR119-G(s) complex structures

Agonists selectively targeting cannabinoid receptor-like G-protein-coupled receptor (GPCR) GPR119 hold promise for treating metabolic disorders while avoiding unwanted side effects. Here we present the cryo-electron microscopy (cryo-EM) structures of the human GPR119-G(s) signaling complexes bound t...

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Detalles Bibliográficos
Autores principales: Qian, Yuxia, Wang, Jiening, Yang, Linlin, Liu, Yanru, Wang, Lina, Liu, Wei, Lin, Yun, Yang, Hong, Ma, Lixin, Ye, Sheng, Wu, Shan, Qiao, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671963/
https://www.ncbi.nlm.nih.gov/pubmed/36396650
http://dx.doi.org/10.1038/s41467-022-34696-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671963/
https://www.ncbi.nlm.nih.gov/pubmed/36396650
http://dx.doi.org/10.1038/s41467-022-34696-6

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