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Activation and signaling mechanism revealed by GPR119-G(s) complex structures

Agonists selectively targeting cannabinoid receptor-like G-protein-coupled receptor (GPCR) GPR119 hold promise for treating metabolic disorders while avoiding unwanted side effects. Here we present the cryo-electron microscopy (cryo-EM) structures of the human GPR119-G(s) signaling complexes bound t...

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Detalles Bibliográficos
Autores principales:	Qian, Yuxia, Wang, Jiening, Yang, Linlin, Liu, Yanru, Wang, Lina, Liu, Wei, Lin, Yun, Yang, Hong, Ma, Lixin, Ye, Sheng, Wu, Shan, Qiao, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671963/ https://www.ncbi.nlm.nih.gov/pubmed/36396650 http://dx.doi.org/10.1038/s41467-022-34696-6

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