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Asymmetric construction of allylicstereogenic carbon center featuring atrifluoromethyl group via enantioselective reductive fluoroalkylation

Emerging as a powerful tool for lead optimization in pharmaceutical research and development, to develop the facile, general protocols that allows the incorporation of fluorine-containing motif in drug candidates has accumulated enormous research interest in recent years. Among these important motif...

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Detalles Bibliográficos
Autores principales: Jin, Ruo-Xing, Wu, Bing-Bing, Bian, Kang-Jie, Yu, Jian-Liang, Dai, Jing-Cheng, Zuo, Ya-Wen, Zhang, Yi-Fan, Wang, Xi-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672039/
https://www.ncbi.nlm.nih.gov/pubmed/36396652
http://dx.doi.org/10.1038/s41467-022-34841-1