Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress

An enhanced NADH/NAD(+) ratio, termed reductive stress, is associated with many diseases. However, whether a downstream sensing pathway exists to mediate pathogenic outcomes remains unclear. Here, we generate a soluble pyridine nucleotide transhydrogenase from Escherichia coli (EcSTH), which can ele...

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Detalles Bibliográficos
Autores principales: Yang, Ronghui, Yang, Chuanzhen, Ma, Lingdi, Zhao, Yiliang, Guo, Zihao, Niu, Jing, Chu, Qiaoyun, Ma, Yingmin, Li, Binghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672040/
https://www.ncbi.nlm.nih.gov/pubmed/36396642
http://dx.doi.org/10.1038/s41467-022-34850-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672040/
https://www.ncbi.nlm.nih.gov/pubmed/36396642
http://dx.doi.org/10.1038/s41467-022-34850-0

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