Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer’s disease with metabolic syndrome

SIRT3 deacetylates mitochondrial proteins, thereby enhancing their function. We have previously demonstrated that Sirt3 gene deletion leads to brain mitochondrial dysfunction and neuroinflammation. We also reported that silencing of Sirt3 gene in APP/PS1 mice results in exacerbation of insulin resis...

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Detalles Bibliográficos
Autores principales: Tyagi, Alpna, Musa, Musa, Labeikovsky, Wladimir, Pugazhenthi, Subbiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672095/
https://www.ncbi.nlm.nih.gov/pubmed/36396721
http://dx.doi.org/10.1038/s41598-022-23652-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672095/
https://www.ncbi.nlm.nih.gov/pubmed/36396721
http://dx.doi.org/10.1038/s41598-022-23652-5

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