Feedforward growth rate control mitigates gene activation burden

Heterologous gene activation causes non-physiological burden on cellular resources that cells are unable to adjust to. Here, we introduce a feedforward controller that actuates growth rate upon activation of a gene of interest (GOI) to compensate for such a burden. The controller achieves this by ac...

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Detalles Bibliográficos
Autores principales: Barajas, Carlos, Huang, Hsin-Ho, Gibson, Jesse, Sandoval, Luis, Del Vecchio, Domitilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672102/
https://www.ncbi.nlm.nih.gov/pubmed/36396941
http://dx.doi.org/10.1038/s41467-022-34647-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672102/
https://www.ncbi.nlm.nih.gov/pubmed/36396941
http://dx.doi.org/10.1038/s41467-022-34647-1

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