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Phosphatidylinositol 4,5-bisphosphate (PIP(2)) facilitates norepinephrine transporter dimerization and modulates substrate efflux
The plasmalemmal norepinephrine transporter (NET) regulates cardiovascular sympathetic activity by clearing extracellular norepinephrine in the synaptic cleft. Here, we investigate the subunit stoichiometry and function of NET using single-molecule fluorescence microscopy and flux assays. In particu...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672106/ https://www.ncbi.nlm.nih.gov/pubmed/36396757 http://dx.doi.org/10.1038/s42003-022-04210-1 |