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Phosphatidylinositol 4,5-bisphosphate (PIP(2)) facilitates norepinephrine transporter dimerization and modulates substrate efflux

The plasmalemmal norepinephrine transporter (NET) regulates cardiovascular sympathetic activity by clearing extracellular norepinephrine in the synaptic cleft. Here, we investigate the subunit stoichiometry and function of NET using single-molecule fluorescence microscopy and flux assays. In particu...

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Detalles Bibliográficos
Autores principales:	Luethi, Dino, Maier, Julian, Rudin, Deborah, Szöllősi, Dániel, Angenoorth, Thomas J. F., Stankovic, Stevan, Schittmayer, Matthias, Burger, Isabella, Yang, Jae-Won, Jaentsch, Kathrin, Holy, Marion, Das, Anand Kant, Brameshuber, Mario, Camacho-Hernandez, Gisela Andrea, Casiraghi, Andrea, Newman, Amy Hauck, Kudlacek, Oliver, Birner-Gruenberger, Ruth, Stockner, Thomas, Schütz, Gerhard J., Sitte, Harald H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672106/ https://www.ncbi.nlm.nih.gov/pubmed/36396757 http://dx.doi.org/10.1038/s42003-022-04210-1

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