Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration

The effectiveness of therapeutic monoclonal antibodies (mAbs) against variants of the SARS-CoV-2 virus is highly variable. As target recognition of mAbs relies on tight binding affinity, we assessed the affinities of five therapeutic mAbs to the receptor binding domain (RBD) of wild type (A), Delta...

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Detalles Bibliográficos
Autores principales: Fiedler, Sebastian, Devenish, Sean R. A., Morgunov, Alexey S., Ilsley, Alison, Ricci, Francesco, Emmenegger, Marc, Kosmoliaptsis, Vasilis, Theel, Elitza S., Mills, John R., Sholukh, Anton M., Aguzzi, Adriano, Iwasaki, Akiko, Lynn, Andrew K., Knowles, Tuomas P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672333/
https://www.ncbi.nlm.nih.gov/pubmed/36396691
http://dx.doi.org/10.1038/s41598-022-22214-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672333/
https://www.ncbi.nlm.nih.gov/pubmed/36396691
http://dx.doi.org/10.1038/s41598-022-22214-z

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