Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif

The Spalt-like 4 transcription factor (SALL4) plays an essential role in controlling the pluripotent property of embryonic stem cells via binding to AT-rich regions of genomic DNA, but structural details on this binding interaction have not been fully characterized. Here, we present crystal structur...

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Detalles Bibliográficos
Autores principales: Ru, Wenwen, Koga, Tomoyuki, Wang, Xiaoyang, Guo, Qiong, Gearhart, Micah D., Zhao, Shidong, Murphy, Mark, Kawakami, Hiroko, Corcoran, Dylan, Zhang, Jiahai, Zhu, Zhongliang, Yao, Xuebiao, Kawakami, Yasuhiko, Xu, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672407/
https://www.ncbi.nlm.nih.gov/pubmed/36257403
http://dx.doi.org/10.1016/j.jbc.2022.102607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672407/
https://www.ncbi.nlm.nih.gov/pubmed/36257403
http://dx.doi.org/10.1016/j.jbc.2022.102607

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