Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling

NOTCH1 is a transmembrane receptor that initiates a signaling pathway involved in embryonic development of adult tissue homeostasis. The extracellular domain of NOTCH1 is composed largely of epidermal growth factor–like repeats (EGFs), many of which can be O-fucosylated at a specific consensus seque...

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Detalles Bibliográficos
Autores principales: Pennarubia, Florian, Ito, Atsuko, Takeuchi, Megumi, Haltiwanger, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672452/
https://www.ncbi.nlm.nih.gov/pubmed/36265581
http://dx.doi.org/10.1016/j.jbc.2022.102616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672452/
https://www.ncbi.nlm.nih.gov/pubmed/36265581
http://dx.doi.org/10.1016/j.jbc.2022.102616

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