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Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling
NOTCH1 is a transmembrane receptor that initiates a signaling pathway involved in embryonic development of adult tissue homeostasis. The extracellular domain of NOTCH1 is composed largely of epidermal growth factor–like repeats (EGFs), many of which can be O-fucosylated at a specific consensus seque...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672452/ https://www.ncbi.nlm.nih.gov/pubmed/36265581 http://dx.doi.org/10.1016/j.jbc.2022.102616 |