First-in-human study to investigate the safety and pharmacokinetics of salvianolic acid A and pharmacokinetic simulation using a physiologically based pharmacokinetic model

Salvianolic acid A (SAA) is a water-soluble phenolic acid component from Salvia miltiorrhiza Bunge currently under development for myocardial protection treatment for coronary heart disease (CHD). We investigated the safety, tolerability, and pharmacokinetics of single and multiple ascending doses o...

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Detalles Bibliográficos
Autores principales: Chen, Jinliang, Ruan, Zourong, Lou, Honggang, Yang, Dandan, Shao, Rong, Xu, Yichao, Hu, Xinhua, Jiang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672460/
https://www.ncbi.nlm.nih.gov/pubmed/36408276
http://dx.doi.org/10.3389/fphar.2022.907208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672460/
https://www.ncbi.nlm.nih.gov/pubmed/36408276
http://dx.doi.org/10.3389/fphar.2022.907208

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