Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2

Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a highly conserved protein tyrosine phosphatase (PTP), which is encoded by PTPN11 and is indispensable during embryonic development. Mutations in PTPN11 in human patients cause aberrant signaling of SHP2, resulting in mu...

Descripción completa

Detalles Bibliográficos
Autores principales: Solman, Maja, Woutersen, Daniëlle T. J., den Hertog, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672471/
https://www.ncbi.nlm.nih.gov/pubmed/36407105
http://dx.doi.org/10.3389/fcell.2022.1046415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672471/
https://www.ncbi.nlm.nih.gov/pubmed/36407105
http://dx.doi.org/10.3389/fcell.2022.1046415

Ejemplares similares