The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides

In this update, we developed a mild, efficient and practical method using fluorosulfuryl imidazolium salt A as an environment friendly promoter for conversion of oximes to nitriles or amides via β-elimination or Beckmann rearrangement in almost quantitative yield in 10 minutes. The target products w...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Yin, Zhao, Yiyong, Shen, Junjie, Zhang, Guofu, Ding, Chengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672908/
https://www.ncbi.nlm.nih.gov/pubmed/36425170
http://dx.doi.org/10.1039/d2ra05890a
_version_ 1784832842086219776
author Cui, Yin
Zhao, Yiyong
Shen, Junjie
Zhang, Guofu
Ding, Chengrong
author_facet Cui, Yin
Zhao, Yiyong
Shen, Junjie
Zhang, Guofu
Ding, Chengrong
author_sort Cui, Yin
collection PubMed
description In this update, we developed a mild, efficient and practical method using fluorosulfuryl imidazolium salt A as an environment friendly promoter for conversion of oximes to nitriles or amides via β-elimination or Beckmann rearrangement in almost quantitative yield in 10 minutes. The target products were generated in gram-scale and could be collected through crystallization without silica gel column purification in excellent yield.
format Online
Article
Text
id pubmed-9672908
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-96729082022-11-23 The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides Cui, Yin Zhao, Yiyong Shen, Junjie Zhang, Guofu Ding, Chengrong RSC Adv Chemistry In this update, we developed a mild, efficient and practical method using fluorosulfuryl imidazolium salt A as an environment friendly promoter for conversion of oximes to nitriles or amides via β-elimination or Beckmann rearrangement in almost quantitative yield in 10 minutes. The target products were generated in gram-scale and could be collected through crystallization without silica gel column purification in excellent yield. The Royal Society of Chemistry 2022-11-18 /pmc/articles/PMC9672908/ /pubmed/36425170 http://dx.doi.org/10.1039/d2ra05890a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Cui, Yin
Zhao, Yiyong
Shen, Junjie
Zhang, Guofu
Ding, Chengrong
The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides
title The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides
title_full The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides
title_fullStr The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides
title_full_unstemmed The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides
title_short The stable “F–SO(2)(+)” donor provides a mild and efficient approach to nitriles and amides
title_sort stable “f–so(2)(+)” donor provides a mild and efficient approach to nitriles and amides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672908/
https://www.ncbi.nlm.nih.gov/pubmed/36425170
http://dx.doi.org/10.1039/d2ra05890a
work_keys_str_mv AT cuiyin thestablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT zhaoyiyong thestablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT shenjunjie thestablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT zhangguofu thestablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT dingchengrong thestablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT cuiyin stablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT zhaoyiyong stablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT shenjunjie stablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT zhangguofu stablefso2donorprovidesamildandefficientapproachtonitrilesandamides
AT dingchengrong stablefso2donorprovidesamildandefficientapproachtonitrilesandamides

Ejemplares similares