ENhANCE trial protocol: A multi-centre, randomised, phase IV trial comparing the efficacy of oxycodone/naloxone prolonged release (OXN PR) versus oxycodone prolonged release (Oxy PR) tablets in patients with advanced cancer

BACKGROUND: Oxycodone is a frequently used opioid in cancer. Opioid-induced constipation (OIC) is common. Oxycodone/Naloxone Prolonged Release (OXN PR) contains naloxone, which mitigates OIC. Trials have either focused on non-cancer pain, or conducted before significant experience of using OXN PR. T...

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Detalles Bibliográficos
Autores principales: Wong, Aaron K., Grobler, Anneke, Le, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672918/
https://www.ncbi.nlm.nih.gov/pubmed/36407843
http://dx.doi.org/10.1016/j.conctc.2022.101036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672918/
https://www.ncbi.nlm.nih.gov/pubmed/36407843
http://dx.doi.org/10.1016/j.conctc.2022.101036

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