Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

In fibrosis remodelling of ECM leads to changes in composition and stiffness. Such changes can have a major impact on cell functions including proliferation, secretory profile and differentiation. Several studies have reported that fibrosis is characterised by increased senescence and accumulating e...

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Detalles Bibliográficos
Autores principales: Blokland, Kaj E. C., Nizamoglu, Mehmet, Habibie, Habibie, Borghuis, Theo, Schuliga, Michael, Melgert, Barbro N., Knight, Darryl A., Brandsma, Corry-Anke, Pouwels, Simon D., Burgess, Janette K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673045/
https://www.ncbi.nlm.nih.gov/pubmed/36408252
http://dx.doi.org/10.3389/fphar.2022.989169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673045/
https://www.ncbi.nlm.nih.gov/pubmed/36408252
http://dx.doi.org/10.3389/fphar.2022.989169

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