1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis

[Image: see text] Alternative mode-of-inhibition of clinically validated targets is an effective strategy for circumventing existing clinical drug resistance. Herein, we report 1,3-diarylpyrazolyl-acylsulfonamides as potent inhibitors of HadAB/BC, a 3-hydroxyl-ACP dehydratase complex required to ite...

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Detalles Bibliográficos
Autores principales: Singh, Vinayak, Grzegorzewicz, Anna E., Fienberg, Stephen, Müller, Rudolf, Khonde, Lutete Peguy, Sanz, Olalla, Alfonso, Salvatore, Urones, Beatriz, Drewes, Gerard, Bantscheff, Marcus, Ghidelli-Disse, Sonja, Ioerger, Thomas R., Angala, Bhanupriya, Liu, Jiuyu, Lee, Richard E., Sacchettini, James C., Krieger, Inna V., Jackson, Mary, Chibale, Kelly, Ghorpade, Sandeep R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673142/
https://www.ncbi.nlm.nih.gov/pubmed/36325756
http://dx.doi.org/10.1021/acsinfecdis.2c00392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673142/
https://www.ncbi.nlm.nih.gov/pubmed/36325756
http://dx.doi.org/10.1021/acsinfecdis.2c00392

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