Dose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment

Poly (ADP-ribose) polymerase (PARP) inhibitors are small-molecule inhibitors of PARP enzymes (including PARP1, PARP2, and PARP3) that exhibit activity against tumor cells with defects in DNA repair. In recent years, five PARP inhibitors, olaparib, niraparib, rucaparib, talazoparib and veliparib, hav...

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Detalles Bibliográficos
Autores principales: Zhao, Dehua, Long, Xiaoqing, Wang, Jisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673935/
https://www.ncbi.nlm.nih.gov/pubmed/36405648
http://dx.doi.org/10.2147/DDDT.S387920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673935/
https://www.ncbi.nlm.nih.gov/pubmed/36405648
http://dx.doi.org/10.2147/DDDT.S387920

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