Deciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue

Deamidation of asparagine (Asn) and isomerization of aspartic acid (Asp) residues are among the most commonly observed spontaneous post-translational modifications (PTMs) in proteins. Understanding and predicting a protein sequence’s propensity for such PTMs can help expedite protein therapeutic dis...

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Detalles Bibliográficos
Autores principales: Irudayanathan, Flaviyan Jerome, Zarzar, Jonathan, Lin, Jasper, Izadi, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673968/
https://www.ncbi.nlm.nih.gov/pubmed/36377085
http://dx.doi.org/10.1080/19420862.2022.2143006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673968/
https://www.ncbi.nlm.nih.gov/pubmed/36377085
http://dx.doi.org/10.1080/19420862.2022.2143006

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