MTCH2 is a mitochondrial outer membrane protein insertase

In the mitochondrial outer membrane, α-helical transmembrane proteins play critical roles in cytoplasmic-mitochondrial communication. Using genome-wide CRISPR screens, we identified MTCH2, and its paralog MTCH1, and showed that it is required for insertion of biophysically diverse tail-anchored (TA)...

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Detalles Bibliográficos
Autores principales: Guna, Alina, Stevens, Taylor A., Inglis, Alison J., Replogle, Joseph M., Esantsi, Theodore K., Muthukumar, Gayathri, Shaffer, Kelly C.L., Wang, Maxine L., Pogson, Angela N., Jones, Jeff J., Lomenick, Brett, Chou, Tsui-Fen, Weissman, Jonathan S., Voorhees, Rebecca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674023/
https://www.ncbi.nlm.nih.gov/pubmed/36264797
http://dx.doi.org/10.1126/science.add1856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674023/
https://www.ncbi.nlm.nih.gov/pubmed/36264797
http://dx.doi.org/10.1126/science.add1856

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