A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines

A prion-like RNA-binding protein, CPEB3, can regulate local translation in dendritic spines. CPEB3 monomers repress translation, whereas CPEB3 aggregates activate translation of its target mRNAs. However, the CPEB3 aggregates, as long-lasting prions, may raise the problem of unregulated translationa...

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Detalles Bibliográficos
Autores principales: Gu, Xinyu, Schafer, Nicholas P., Bueno, Carlos, Lu, Wei, Wolynes, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674179/
https://www.ncbi.nlm.nih.gov/pubmed/36346822
http://dx.doi.org/10.1371/journal.pcbi.1010657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674179/
https://www.ncbi.nlm.nih.gov/pubmed/36346822
http://dx.doi.org/10.1371/journal.pcbi.1010657

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