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A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines
A prion-like RNA-binding protein, CPEB3, can regulate local translation in dendritic spines. CPEB3 monomers repress translation, whereas CPEB3 aggregates activate translation of its target mRNAs. However, the CPEB3 aggregates, as long-lasting prions, may raise the problem of unregulated translationa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674179/ https://www.ncbi.nlm.nih.gov/pubmed/36346822 http://dx.doi.org/10.1371/journal.pcbi.1010657 |