Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα

Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that perform multiple and important cellular functions. The protein investigated here belongs to class IA of the PI3Ks; it is a dimer consisting of a catalytic subunit, p110α, and a regulatory subunit, p85α, and is referred to as PI3Kα...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiao, Zhou, Qingtong, Hart, Jonathan R., Xu, Yingna, Yang, Su, Yang, Dehua, Vogt, Peter K., Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674216/
https://www.ncbi.nlm.nih.gov/pubmed/36343266
http://dx.doi.org/10.1073/pnas.2215621119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674216/
https://www.ncbi.nlm.nih.gov/pubmed/36343266
http://dx.doi.org/10.1073/pnas.2215621119

Ejemplares similares