Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

Developing peptide-based tools to fine-tune growth signaling pathways, in particular molecules with exquisite selectivity and high affinities, opens up opportunities for cellular reprogramming in tissue regeneration. Here, we present a library based on cystine-knot peptides (CKPs) that incorporate m...

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Detalles Bibliográficos
Autores principales: Hansen, Simon, Zhang, Yingnan, Hwang, Sunhee, Nabhan, Ahmad, Li, Wanqing, Fuhrmann, Jakob, Kschonsak, Yvonne, Zhou, Lijuan, Nile, Aaron H., Gao, Xinxin, Piskol, Robert, de Sousa e Melo, Felipe, de Sauvage, Frederic J., Hannoush, Rami N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674260/
https://www.ncbi.nlm.nih.gov/pubmed/36343233
http://dx.doi.org/10.1073/pnas.2207327119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674260/
https://www.ncbi.nlm.nih.gov/pubmed/36343233
http://dx.doi.org/10.1073/pnas.2207327119

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