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Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

Developing peptide-based tools to fine-tune growth signaling pathways, in particular molecules with exquisite selectivity and high affinities, opens up opportunities for cellular reprogramming in tissue regeneration. Here, we present a library based on cystine-knot peptides (CKPs) that incorporate m...

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Detalles Bibliográficos
Autores principales:	Hansen, Simon, Zhang, Yingnan, Hwang, Sunhee, Nabhan, Ahmad, Li, Wanqing, Fuhrmann, Jakob, Kschonsak, Yvonne, Zhou, Lijuan, Nile, Aaron H., Gao, Xinxin, Piskol, Robert, de Sousa e Melo, Felipe, de Sauvage, Frederic J., Hannoush, Rami N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Physical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674260/ https://www.ncbi.nlm.nih.gov/pubmed/36343233 http://dx.doi.org/10.1073/pnas.2207327119

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