Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin

Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid–liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular con...

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Detalles Bibliográficos
Autores principales: Babcock, Rachel L., Pruitt, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674272/
https://www.ncbi.nlm.nih.gov/pubmed/36383195
http://dx.doi.org/10.1083/jcb.202211001
Descripción
Sumario:Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid–liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane.

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