Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin

Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid–liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular con...

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Detalles Bibliográficos
Autores principales: Babcock, Rachel L., Pruitt, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674272/
https://www.ncbi.nlm.nih.gov/pubmed/36383195
http://dx.doi.org/10.1083/jcb.202211001
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author Babcock, Rachel L.
Pruitt, Kevin
author_facet Babcock, Rachel L.
Pruitt, Kevin
author_sort Babcock, Rachel L.
collection PubMed
description Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid–liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane.
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spelling pubmed-96742722023-05-16 Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin Babcock, Rachel L. Pruitt, Kevin J Cell Biol Spotlight Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid–liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane. Rockefeller University Press 2022-11-16 /pmc/articles/PMC9674272/ /pubmed/36383195 http://dx.doi.org/10.1083/jcb.202211001 Text en © 2022 Babcock and Pruitt https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Babcock, Rachel L.
Pruitt, Kevin
Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
title Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
title_full Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
title_fullStr Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
title_full_unstemmed Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
title_short Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
title_sort letting go: dishevelled phase separation recruits axin to stabilize β-catenin
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674272/
https://www.ncbi.nlm.nih.gov/pubmed/36383195
http://dx.doi.org/10.1083/jcb.202211001
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