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Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice()

Calcium-calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes mellitus (DM), leading to the overproduction of collagen in the myocardium. We hypothesized that CaMKII plays a role in the development of diabetic nephropathy (DN). Streptozotocin (STZ) injection into FVB wild-type m...

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Detalles Bibliográficos
Autores principales: Mikhailov, Alexei V., Liu, Yixi, Cheng, Heng-Jie, Lin, Jen-Jar, Cheng, Che Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674542/
https://www.ncbi.nlm.nih.gov/pubmed/36411910
http://dx.doi.org/10.1016/j.heliyon.2022.e11653