Prioritizing autoimmunity risk variants for functional analyses by fine-mapping mutations under natural selection

Pathogen-driven selection shaped adaptive mutations in immunity genes, including those contributing to inflammatory disorders. Functional characterization of such adaptive variants can shed light on disease biology and past adaptations. This popular idea, however, was difficult to test due to challe...

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Detalles Bibliográficos
Autores principales: Pankratov, Vasili, Yunusbaeva, Milyausha, Ryakhovsky, Sergei, Zarodniuk, Maksym, Yunusbayev, Bayazit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674589/
https://www.ncbi.nlm.nih.gov/pubmed/36400766
http://dx.doi.org/10.1038/s41467-022-34461-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674589/
https://www.ncbi.nlm.nih.gov/pubmed/36400766
http://dx.doi.org/10.1038/s41467-022-34461-9

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