Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense

Resistance to African trypanosomes in humans relies in part on the high affinity targeting of a trypanosome lytic factor 1 (TLF1) to a trypanosome haptoglobin-hemoglobin receptor (HpHbR). While TLF1 avoidance by the inactivation of HpHbR contributes to Trypanosoma brucei gambiense human infectivity,...

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Detalles Bibliográficos
Autores principales: Horáková, Eva, Lecordier, Laurence, Cunha, Paula, Sobotka, Roman, Changmai, Piya, Langedijk, Catharina J. M., Abbeele, Jan Van Den, Vanhollebeke, Benoit, Lukeš, Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674590/
https://www.ncbi.nlm.nih.gov/pubmed/36400774
http://dx.doi.org/10.1038/s41467-022-34501-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674590/
https://www.ncbi.nlm.nih.gov/pubmed/36400774
http://dx.doi.org/10.1038/s41467-022-34501-4

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