Mutant p53 in cancer: from molecular mechanism to therapeutic modulation

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed “gain-of-function”. Emerging evidence suggests that mutp53 is highly ass...

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Detalles Bibliográficos
Autores principales: Chen, Xiaohua, Zhang, Taotao, Su, Wei, Dou, Zhihui, Zhao, Dapeng, Jin, Xiaodong, Lei, Huiwen, Wang, Jing, Xie, Xiaodong, Cheng, Bo, Li, Qiang, Zhang, Hong, Di, Cuixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674619/
https://www.ncbi.nlm.nih.gov/pubmed/36400749
http://dx.doi.org/10.1038/s41419-022-05408-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674619/
https://www.ncbi.nlm.nih.gov/pubmed/36400749
http://dx.doi.org/10.1038/s41419-022-05408-1

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