An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Multiplexed assays of variant effects (MAVEs) guide clinical variant interpretation and reveal disease mechanisms. To date, MAVEs have focussed on a single mutation type—amino acid (AA) substitutions—despite the diversity of coding variants that cause disease. Here we use Deep Indel Mutagenesis (DIM...

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Detalles Bibliográficos
Autores principales: Seuma, Mireia, Lehner, Ben, Bolognesi, Benedetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674652/
https://www.ncbi.nlm.nih.gov/pubmed/36400770
http://dx.doi.org/10.1038/s41467-022-34742-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674652/
https://www.ncbi.nlm.nih.gov/pubmed/36400770
http://dx.doi.org/10.1038/s41467-022-34742-3

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