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Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions
DNA replicates once per cell cycle. Interfering with the regulation of DNA replication initiation generates genome instability through over-replication and has been linked to early stages of cancer development. Here, we engineer genetic systems in budding yeast to induce unscheduled replication in a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674678/ https://www.ncbi.nlm.nih.gov/pubmed/36400763 http://dx.doi.org/10.1038/s41467-022-34379-2 |